NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.

Sansal, I; Dupont, E; Toru, D; Evrard, C; Rouget, P

Sansal, I; Dupont, E; Toru, D; Evrard, C; Rouget, P.

Affiliation

Sansal I; Unité de Génétique Oncologique, CNRS-UMR-1599, Institut Gustave Roussy, PR-1, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

Oncogene ; 19(43): 5000-9, 2000 Oct 12.

Article in En | MEDLINE | ID: mdl-11042687

Subject(s)

Carrier Proteins; DNA-Binding Proteins/metabolism; DNA/metabolism; Nerve Tissue Proteins/physiology; Transcription Factors/metabolism; Transcription, Genetic/physiology; Animals; Binding Sites; Cell Cycle Proteins/metabolism; DNA/antagonists & inhibitors; DNA/genetics; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/genetics; E2F Transcription Factors; E2F1 Transcription Factor; Genes, Reporter/genetics; Glutathione Transferase/genetics; Humans; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Peptide Mapping; Promoter Regions, Genetic; Rabbits; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/pharmacology; Retinoblastoma-Binding Protein 1; Transcription Factor DP1; Transcription Factors/antagonists & inhibitors; Transcription Factors/genetics; Transcription, Genetic/drug effects; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Transcription, Genetic / DNA / Carrier Proteins / DNA-Binding Proteins / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2000 Type: Article Affiliation country: France

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