Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase.

White, A W; Almassy, R; Calvert, A H; Curtin, N J; Griffin, R J; Hostomsky, Z; Maegley, K; Newell, D R; Srinivasan, S; Golding, B T

White, A W; Almassy, R; Calvert, A H; Curtin, N J; Griffin, R J; Hostomsky, Z; Maegley, K; Newell, D R; Srinivasan, S; Golding, B T.

Affiliation

White AW; Department of Chemistry, Bedson Building, The University, Newcastle upon Tyne NE1 7RU, UK.

J Med Chem ; 43(22): 4084-97, 2000 Nov 02.

Article in En | MEDLINE | ID: mdl-11063605

Subject(s)

Benzimidazoles/chemistry; Benzimidazoles/chemical synthesis; Dacarbazine/analogs & derivatives; Enzyme Inhibitors/chemical synthesis; Poly(ADP-ribose) Polymerase Inhibitors; Antineoplastic Agents/pharmacology; Benzimidazoles/pharmacology; Crystallography, X-Ray; Dacarbazine/pharmacology; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Humans; Models, Molecular; Structure-Activity Relationship; Temozolomide; Topotecan/pharmacology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Dacarbazine / Enzyme Inhibitors / Poly(ADP-ribose) Polymerase Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2000 Type: Article Affiliation country: United kingdom

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