Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane.

Jabado, N; Jankowski, A; Dougaparsad, S; Picard, V; Grinstein, S; Gros, P

Jabado, N; Jankowski, A; Dougaparsad, S; Picard, V; Grinstein, S; Gros, P.

Affiliation

Jabado N; Department of Biochemistry, McGill University, Montreal H3G-1Y6, Quebec, Canada.

J Exp Med ; 192(9): 1237-48, 2000 Nov 06.

Article in En | MEDLINE | ID: mdl-11067873

Subject(s)

Carrier Proteins/metabolism; Cation Transport Proteins; Intracellular Membranes/metabolism; Iron-Binding Proteins; Macrophages, Peritoneal/metabolism; Manganese/metabolism; Membrane Proteins/metabolism; Phagosomes/immunology; Phagosomes/metabolism; Animals; Biological Transport/drug effects; Cations, Divalent/metabolism; Ethylenediamines/pharmacology; Fluorescent Dyes/chemical synthesis; Fluorescent Dyes/metabolism; Fura-2/metabolism; Hydrogen-Ion Concentration; Intracellular Membranes/drug effects; Macrophages, Peritoneal/cytology; Macrophages, Peritoneal/drug effects; Macrophages, Peritoneal/immunology; Mice; Mice, Knockout; Microscopy, Fluorescence; Mutation; Spectrometry, Fluorescence; Thapsigargin/pharmacology; Zymosan/analogs & derivatives; Zymosan/chemical synthesis; Zymosan/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagosomes / Carrier Proteins / Macrophages, Peritoneal / Cation Transport Proteins / Iron-Binding Proteins / Intracellular Membranes / Manganese / Membrane Proteins Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Exp Med Year: 2000 Type: Article Affiliation country: Canada

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