Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts.

Reinholz, G G; Getz, B; Pederson, L; Sanders, E S; Subramaniam, M; Ingle, J N; Spelsberg, T C

Reinholz, G G; Getz, B; Pederson, L; Sanders, E S; Subramaniam, M; Ingle, J N; Spelsberg, T C.

Affiliation

Reinholz GG; Department of Biochemistry and Molecullar Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Cancer Res ; 60(21): 6001-7, 2000 Nov 01.

Article in En | MEDLINE | ID: mdl-11085520

Subject(s)

Diphosphonates/pharmacology; Osteoblasts/drug effects; Alkaline Phosphatase/metabolism; Anti-Inflammatory Agents/pharmacology; Antineoplastic Agents/pharmacology; Bone Development/drug effects; Calcification, Physiologic/drug effects; Cell Differentiation/drug effects; Cell Division/drug effects; Cells, Cultured; Chelating Agents/pharmacology; Collagen/metabolism; Edetic Acid/pharmacology; Etidronic Acid/pharmacology; Fetus; Gene Expression/drug effects; Humans; Imidazoles/pharmacology; Osteoblasts/cytology; Osteoblasts/physiology; Pamidronate; Proteins/metabolism; Zoledronic Acid

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Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Diphosphonates Limits: Humans Language: En Journal: Cancer Res Year: 2000 Type: Article Affiliation country: United States

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