Novel long-acting somatostatin analog with endocrine selectivity: potent suppression of growth hormone but not of insulin.

Afargan, M; Janson, E T; Gelerman, G; Rosenfeld, R; Ziv, O; Karpov, O; Wolf, A; Bracha, M; Shohat, D; Liapakis, G; Gilon, C; Hoffman, A; Stephensky, D; Oberg, K

Afargan, M; Janson, E T; Gelerman, G; Rosenfeld, R; Ziv, O; Karpov, O; Wolf, A; Bracha, M; Shohat, D; Liapakis, G; Gilon, C; Hoffman, A; Stephensky, D; Oberg, K.

Affiliation

Afargan M; Departments of Medicinal Sciences and Endocrine Oncology, University Hospital SE 75185, Uppsala, Sweden.

Endocrinology ; 142(1): 477-86, 2001 Jan.

Article in En | MEDLINE | ID: mdl-11145612

Subject(s)

Human Growth Hormone/metabolism; Insulin/metabolism; Receptors, Somatostatin/physiology; Somatostatin/metabolism; Somatostatin/pharmacology; Animals; Binding, Competitive; Carcinoid Tumor; Cloning, Molecular; Cyclic AMP; Glucagon/pharmacology; Humans; Insulin Secretion; Kinetics; Male; Octreotide/pharmacokinetics; Octreotide/pharmacology; Pancreatic Neoplasms; Peptide Library; Radioligand Assay; Rats; Rats, Wistar; Receptors, Somatostatin/drug effects; Recombinant Proteins/metabolism; Somatostatin/analogs & derivatives; Somatostatin/pharmacokinetics; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Somatostatin / Receptors, Somatostatin / Human Growth Hormone / Insulin Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Endocrinology Year: 2001 Type: Article Affiliation country: Sweden

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