DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.

Raveh, T; Droguett, G; Horwitz, M S; DePinho, R A; Kimchi, A

Raveh, T; Droguett, G; Horwitz, M S; DePinho, R A; Kimchi, A.

Affiliation

Raveh T; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.

Nat Cell Biol ; 3(1): 1-7, 2001 Jan.

Article in En | MEDLINE | ID: mdl-11146619

Subject(s)

Apoptosis/genetics; Calcium-Calmodulin-Dependent Protein Kinases/deficiency; Carrier Proteins; Cell Cycle Proteins; Cell Transformation, Neoplastic/metabolism; DNA-Binding Proteins; Genes, Tumor Suppressor/physiology; Genes, cdc/physiology; Proteins/metabolism; Tumor Suppressor Protein p53/metabolism; Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases/genetics; Cell Division/genetics; Cell Line, Transformed/cytology; Cell Line, Transformed/enzymology; Cell Transformation, Neoplastic/genetics; Death-Associated Protein Kinases; E2F Transcription Factors; E2F1 Transcription Factor; Fetus; Fibroblasts/cytology; Fibroblasts/enzymology; Gene Expression Regulation, Neoplastic/physiology; Genes, myc/physiology; Mice; Mice, Knockout; Oncogenes/physiology; Proteins/genetics; Retinoblastoma-Binding Protein 1; Signal Transduction/genetics; Transcription Factor DP1; Transcription Factors/genetics; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Carrier Proteins / Cell Transformation, Neoplastic / Genes, Tumor Suppressor / Tumor Suppressor Protein p53 / Apoptosis / Calcium-Calmodulin-Dependent Protein Kinases / Genes, cdc / Cell Cycle Proteins / DNA-Binding Proteins Limits: Animals Language: En Journal: Nat Cell Biol Year: 2001 Type: Article Affiliation country: Israel

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