Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis.

Ramalingam, T S; West, A P; Lebrón, J A; Nangiana, J S; Hogan, T H; Enns, C A; Bjorkman, P J

Ramalingam, T S; West, A P; Lebrón, J A; Nangiana, J S; Hogan, T H; Enns, C A; Bjorkman, P J.

Affiliation

Ramalingam TS; Division of Biology 156-29, California Institute of Technology, Pasadena, California 91125, USA.

Nat Cell Biol ; 2(12): 953-7, 2000 Dec.

Article in En | MEDLINE | ID: mdl-11146662

Subject(s)

HLA Antigens/metabolism; Histocompatibility Antigens Class I/metabolism; Iron/metabolism; Membrane Proteins; Receptors, Transferrin/metabolism; Biological Transport, Active; Cell Line; Cell Polarity; Endocytosis; Endosomes/metabolism; Epithelial Cells/metabolism; Green Fluorescent Proteins; HLA Antigens/genetics; Hemochromatosis/genetics; Hemochromatosis/immunology; Hemochromatosis/metabolism; Hemochromatosis Protein; Histocompatibility Antigens Class I/genetics; Homeostasis; Humans; Luminescent Proteins/genetics; Luminescent Proteins/metabolism; Microscopy, Confocal; Models, Biological; Mutation; Protein Binding; Receptors, LDL/genetics; Receptors, LDL/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Transferrin / Histocompatibility Antigens Class I / HLA Antigens / Iron / Membrane Proteins Limits: Humans Language: En Journal: Nat Cell Biol Year: 2000 Type: Article Affiliation country: United States

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