Identification and characterization of A-105972, an antineoplastic agent.

Wu-Wong, J R; Alder, J D; Alder, L; Burns, D J; Han, E K; Credo, B; Tahir, S K; Dayton, B D; Ewing, P J; Chiou, W J

Wu-Wong, J R; Alder, J D; Alder, L; Burns, D J; Han, E K; Credo, B; Tahir, S K; Dayton, B D; Ewing, P J; Chiou, W J.

Affiliation

Wu-Wong JR; Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA. ruth.r.wuwong@abbott.com

Cancer Res ; 61(4): 1486-92, 2001 Feb 15.

Article in En | MEDLINE | ID: mdl-11245455

Subject(s)

Antineoplastic Agents/pharmacology; Oxadiazoles/pharmacology; Animals; Antineoplastic Agents/metabolism; Apoptosis/drug effects; Cell Cycle/drug effects; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; Leukemia P388/drug therapy; Leukemia P388/pathology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Microtubules/drug effects; Microtubules/metabolism; Oxadiazoles/metabolism; Phosphorylation/drug effects; Protein Binding; Proto-Oncogene Proteins c-bcl-2/metabolism; Tubulin/metabolism; Tumor Cells, Cultured/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2001 Type: Article Affiliation country: United States

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