Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

Lee, J Y; Sohn, K H; Rhee, S H; Hwang, D

Lee, J Y; Sohn, K H; Rhee, S H; Hwang, D.

Affiliation

Lee JY; Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA.

J Biol Chem ; 276(20): 16683-9, 2001 May 18.

Article in En | MEDLINE | ID: mdl-11278967

Subject(s)

Drosophila Proteins; Fatty Acids, Nonesterified/pharmacology; Fatty Acids, Unsaturated/pharmacology; Gene Expression Regulation, Enzymologic/drug effects; Isoenzymes/genetics; Membrane Glycoproteins/physiology; Prostaglandin-Endoperoxide Synthases/genetics; Receptors, Cell Surface/physiology; Adenocarcinoma; Animals; Base Sequence; Cell Line; Colonic Neoplasms; Consensus Sequence; Cyclooxygenase 2; Docosahexaenoic Acids/pharmacology; Enzyme Induction/drug effects; Genes, Reporter; Humans; Isoenzymes/biosynthesis; Lauric Acids/pharmacology; Lipid A/pharmacology; Lipopolysaccharides/pharmacology; Macrophages; Membrane Glycoproteins/drug effects; Membrane Proteins; Mice; Monocytes; NF-kappa B/metabolism; Nitric Oxide Synthase/genetics; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases/biosynthesis; Receptors, Cell Surface/drug effects; Toll-Like Receptor 4; Toll-Like Receptors; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Gene Expression Regulation, Enzymologic / Prostaglandin-Endoperoxide Synthases / Receptors, Cell Surface / Drosophila Proteins / Fatty Acids, Nonesterified / Fatty Acids, Unsaturated / Isoenzymes Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2001 Type: Article Affiliation country: United States

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