Complement facilitates early prion pathogenesis.

Klein, M A; Kaeser, P S; Schwarz, P; Weyd, H; Xenarios, I; Zinkernagel, R M; Carroll, M C; Verbeek, J S; Botto, M; Walport, M J; Molina, H; Kalinke, U; Acha-Orbea, H; Aguzzi, A

Klein, M A; Kaeser, P S; Schwarz, P; Weyd, H; Xenarios, I; Zinkernagel, R M; Carroll, M C; Verbeek, J S; Botto, M; Walport, M J; Molina, H; Kalinke, U; Acha-Orbea, H; Aguzzi, A.

Affiliation

Klein MA; Institute of Neuropathology, University of Zurich, Schmelzbergstrasse, Zurich, Switzerland.

Nat Med ; 7(4): 488-92, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11283678

Subject(s)

Complement System Proteins/metabolism; Prion Diseases/etiology; Prion Diseases/immunology; Animals; Base Sequence; Brain/metabolism; Brain/pathology; Complement System Proteins/deficiency; Complement System Proteins/genetics; DNA Primers/genetics; Disease Models, Animal; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Prion Diseases/pathology; Prions/metabolism; Receptors, Complement/deficiency; Receptors, Complement/genetics; Receptors, Complement/metabolism; Scrapie/etiology; Scrapie/immunology; Scrapie/pathology; Spleen/immunology; Spleen/metabolism; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Complement System Proteins / Prion Diseases Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2001 Type: Article Affiliation country: Switzerland

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