Adenoviral delivery of a leukocyte-type 12 lipoxygenase ribozyme inhibits effects of glucose and platelet-derived growth factor in vascular endothelial and smooth muscle cells.

Patricia, M K; Natarajan, R; Dooley, A N; Hernandez, F; Gu, J L; Berliner, J A; Rossi, J J; Nadler, J L; Meidell, R S; Hedrick, C C

Patricia, M K; Natarajan, R; Dooley, A N; Hernandez, F; Gu, J L; Berliner, J A; Rossi, J J; Nadler, J L; Meidell, R S; Hedrick, C C.

Affiliation

Patricia MK; Division of Cardiology, Department of Experimental Pathology, University of California Los Angeles, USA.

Circ Res ; 88(7): 659-65, 2001 Apr 13.

Article in En | MEDLINE | ID: mdl-11304487

Subject(s)

Endothelium, Vascular/drug effects; Glucose/antagonists & inhibitors; Lipoxygenase Inhibitors; Muscle, Smooth, Vascular/drug effects; Platelet-Derived Growth Factor/antagonists & inhibitors; RNA, Catalytic/pharmacology; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid/metabolism; Adenoviridae/genetics; Animals; Aorta; Arachidonate 12-Lipoxygenase/genetics; Arachidonate 12-Lipoxygenase/metabolism; Cell Adhesion/drug effects; Cell Movement/drug effects; Cells, Cultured; Endothelium, Vascular/cytology; Endothelium, Vascular/metabolism; Gene Expression/drug effects; Gene Transfer Techniques; Genetic Vectors/genetics; Genetic Vectors/pharmacology; Glucose/metabolism; Glucose/pharmacology; Isoenzymes/antagonists & inhibitors; Isoenzymes/genetics; Isoenzymes/metabolism; Leukocytes/enzymology; Monocytes/drug effects; Monocytes/metabolism; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/metabolism; Platelet-Derived Growth Factor/metabolism; Platelet-Derived Growth Factor/pharmacology; RNA, Catalytic/genetics; RNA, Catalytic/metabolism; RNA, Messenger/antagonists & inhibitors; Substrate Specificity/genetics; Swine

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Collection: 01-internacional Database: MEDLINE Main subject: Platelet-Derived Growth Factor / Endothelium, Vascular / RNA, Catalytic / Lipoxygenase Inhibitors / Glucose / Muscle, Smooth, Vascular Language: En Journal: Circ Res Year: 2001 Type: Article Affiliation country: United States

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