Co-localization of 5-HT(1B/1D/1F) receptors and glutamate in trigeminal ganglia in rats.
Neuroreport
; 12(8): 1589-91, 2001 Jun 13.
Article
in En
| MEDLINE
| ID: mdl-11409721
ABSTRACT
Anti-migraine triptan drugs are 5-HT(1B/1D) receptor agonists which are thought to block the neurotransmitter/neuropeptide release from sensory nerve terminals and directly constrict blood vessel smooth muscles. In the present study, we have investigated the anatomical basis for a possible modulation of glutamate release from trigeminal ganglion neurons by 5-HT(1B/1D) receptor agonists and by 5-HT1F receptor agonists, using double immunohistochemical staining technique in the rat. The majority of 5-HT1B, 5-HT1D or 5-HT1F receptor positive neurons were also glutamate positive, but both 5-HT1B, 5-HT1D or 5-HT1F receptor single-labeled and glutamate single-labeled neurons were observed. These results suggest that 5-HT(1B/1D/1F) receptor agonists may modulate glutamate release, and that one mechanism of their anti-migraine action could be the blockade of glutamate release.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trigeminal Ganglion
/
Receptors, Serotonin
/
Glutamic Acid
Limits:
Animals
Language:
En
Journal:
Neuroreport
Journal subject:
NEUROLOGIA
Year:
2001
Type:
Article
Affiliation country:
United kingdom