N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.

Wang, H; Maurer, B J; Reynolds, C P; Cabot, M C

Wang, H; Maurer, B J; Reynolds, C P; Cabot, M C.

Affiliation

Wang H; John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA.

Cancer Res ; 61(13): 5102-5, 2001 Jul 01.

Article in En | MEDLINE | ID: mdl-11431347

Subject(s)

Acyltransferases/metabolism; Antineoplastic Agents/pharmacology; Ceramides/biosynthesis; Fenretinide/pharmacology; Neuroblastoma/enzymology; Oxidoreductases/metabolism; Sphingosine/analogs & derivatives; Acyltransferases/biosynthesis; Enzyme Activation/drug effects; Enzyme Induction/drug effects; Humans; Neuroblastoma/metabolism; Oxidoreductases/biosynthesis; Serine C-Palmitoyltransferase; Sphingosine/biosynthesis; Tumor Cells, Cultured/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Sphingosine / Acyltransferases / Ceramides / Fenretinide / Neuroblastoma / Antineoplastic Agents Limits: Humans Language: En Journal: Cancer Res Year: 2001 Type: Article Affiliation country: United States

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