Vanilloid receptor homologue, VRL1, is expressed by both A- and C-fiber sensory neurons.
Neuroreport
; 12(17): 3693-5, 2001 Dec 04.
Article
in En
| MEDLINE
| ID: mdl-11726776
ABSTRACT
The capsaicin receptor (VR1) homologue, VRL1, is thought to be responsible for transducing high-threshold heat responses in Adelta-fiber neurons. In the present study, the expression of VRL1 by A- or C-fiber sensory neurons in rats was investigated by using a VRL1 and 200 kDa neurofilament (NF200, an A-fiber marker) double immunohistochemical staining method. Approximately 46% of VRL-positive neurons were NF200 positive. Though double-labeled neurons tended to be medium to large, many VRL1 single-labeled neurons were large. Dense VRL1 immunoreactivity was also found in laminae I and II of the spinal dorsal horn, where nociceptive Adelta- and C-fibers normally terminate. These results suggest that both C-fiber and Adelta-fiber primary sensory neurons express VRL1, and VRL1 may play an important role in nociception.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Drug
/
Nociceptors
/
Ganglia, Spinal
/
Hyperalgesia
/
Nerve Fibers
/
Nerve Fibers, Myelinated
/
Neurons, Afferent
Limits:
Animals
Language:
En
Journal:
Neuroreport
Journal subject:
NEUROLOGIA
Year:
2001
Type:
Article
Affiliation country:
United kingdom