Clonal chromosomal alterations in fibroadenomas of the breast.
Cancer Genet Cytogenet
; 131(2): 120-4, 2001 Dec.
Article
in En
| MEDLINE
| ID: mdl-11750051
ABSTRACT
A cytogenetic study on short-term cell cultures from 10 fibroadenomas of the breast is reported. Clonal chromosomal alterations were observed in all cases analyzed, involving preferentially chromosomes X, 12, 14, 20, and 22. Normal karyotypes were found in 34.9% of the cells. The present findings are discussed together with the reports on fibroadenomas and other benign lesions of the breast described in the literature. Although no specific chromosome abnormality to date can be attributed to a particular type of benign breast pathology, some recurrent alterations are starting to emerge and may characterize these benign breast lesions, differentiating them from their malignant counterparts.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Chromosome Aberrations
/
Fibroadenoma
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Cancer Genet Cytogenet
Year:
2001
Type:
Article
Affiliation country:
Brazil