Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.

Hay, Douglas W P; Giardina, Giuseppe A M; Griswold, Don E; Underwood, David C; Kotzer, Charles J; Bush, Brian; Potts, William; Sandhu, Punam; Lundberg, Dave; Foley, James J; Schmidt, Dulcie B; Martin, Lenox D; Kilian, David; Legos, Jeffrey J; Barone, Frank C; Luttmann, Mark A; Grugni, Mario; Raveglia, Luca F; Sarau, Henry M

Hay, Douglas W P; Giardina, Giuseppe A M; Griswold, Don E; Underwood, David C; Kotzer, Charles J; Bush, Brian; Potts, William; Sandhu, Punam; Lundberg, Dave; Foley, James J; Schmidt, Dulcie B; Martin, Lenox D; Kilian, David; Legos, Jeffrey J; Barone, Frank C; Luttmann, Mark A; Grugni, Mario; Raveglia, Luca F; Sarau, Henry M.

Affiliation

Hay DW; GlaxoSmithKline, Department of Pulmonary Biology, King of Prussia, Pennsylvania 19406, USA. douglas_w_hay@sbphrd.com

J Pharmacol Exp Ther ; 300(1): 314-23, 2002 Jan.

Article in En | MEDLINE | ID: mdl-11752131

Subject(s)

Acetates/pharmacology; Antitussive Agents/pharmacology; Bronchial Hyperreactivity/prevention & control; Cough/prevention & control; Quinolines/pharmacology; Receptors, Neurokinin-3/antagonists & inhibitors; Receptors, Tachykinin/antagonists & inhibitors; Substance P/analogs & derivatives; Animals; Behavior, Animal; Bronchial Hyperreactivity/chemically induced; Calcium/metabolism; Central Nervous System/drug effects; Central Nervous System/metabolism; Citric Acid; Cloning, Molecular; Cough/chemically induced; Guinea Pigs; In Vitro Techniques; Iris/drug effects; Male; Mice; Mice, Inbred BALB C; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Neurokinin A/pharmacology; Peptide Fragments/pharmacology; Pupil/drug effects; Rabbits; Radioligand Assay; Rats; Recombinant Proteins/metabolism; Substance P/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Antitussive Agents / Quinolines / Substance P / Bronchial Hyperreactivity / Receptors, Tachykinin / Receptors, Neurokinin-3 / Cough / Acetates Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2002 Type: Article Affiliation country: United States

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