Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.

Ng, Howard P; Buckman, Brad O; Eagen, Keith A; Guilford, William J; Kochanny, Monica J; Mohan, Raju; Shaw, Kenneth J; Wu, Shung C; Lentz, Dao; Liang, Amy; Trinh, Lan; Ho, Elena; Smith, David; Subramanyam, Babu; Vergona, Ron; Walters, Janette; White, Kathy A; Sullivan, Mark E; Morrissey, Michael M; Phillips, Gary B

Ng, Howard P; Buckman, Brad O; Eagen, Keith A; Guilford, William J; Kochanny, Monica J; Mohan, Raju; Shaw, Kenneth J; Wu, Shung C; Lentz, Dao; Liang, Amy; Trinh, Lan; Ho, Elena; Smith, David; Subramanyam, Babu; Vergona, Ron; Walters, Janette; White, Kathy A; Sullivan, Mark E; Morrissey, Michael M; Phillips, Gary B.

Affiliation

Ng HP; Pharmaceuticals Research, Berlex Biosciences, 15049 San Pablo Avenue, PO Box 4099, Richmond, CA 94804-0099, USA.

Bioorg Med Chem ; 10(3): 657-66, 2002 Mar.

Article in En | MEDLINE | ID: mdl-11814853

Subject(s)

Factor Xa Inhibitors; Pyridines/chemical synthesis; Serine Proteinase Inhibitors/chemical synthesis; Administration, Oral; Animals; Biological Availability; Cattle; Dogs; Drug Design; Fibrinolytic Agents/chemical synthesis; Heterocyclic Compounds, 4 or More Rings/chemical synthesis; Heterocyclic Compounds, 4 or More Rings/pharmacokinetics; Heterocyclic Compounds, 4 or More Rings/pharmacology; Pyridines/pharmacokinetics; Pyridines/pharmacology; Rats; Serine Proteinase Inhibitors/pharmacokinetics; Serine Proteinase Inhibitors/pharmacology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Serine Proteinase Inhibitors / Factor Xa Inhibitors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Type: Article Affiliation country: United States

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