A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K.

Patil, Ashok D; Freyer, Alan J; Killmer, Lew; Offen, Priscilla; Taylor, Paul B; Votta, Bartholomew J; Johnson, Randall K

Patil, Ashok D; Freyer, Alan J; Killmer, Lew; Offen, Priscilla; Taylor, Paul B; Votta, Bartholomew J; Johnson, Randall K.

Affiliation

Patil AD; Drug Discovery, Millennium Pharmaceuticals Inc., 75-5 Sidney Street, Cambridge, Massachusetts 02139, USA.

J Nat Prod ; 65(4): 624-7, 2002 Apr.

Article in En | MEDLINE | ID: mdl-11975520

Subject(s)

Cathepsins/antagonists & inhibitors; Chalcone/isolation & purification; Cysteine Proteinase Inhibitors/isolation & purification; Flavonoids/isolation & purification; Moraceae/chemistry; Cathepsin K; Chalcone/analogs & derivatives; Chalcone/chemistry; Chalcone/pharmacology; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors/chemistry; Cysteine Proteinase Inhibitors/pharmacology; Flavonoids/chemistry; Flavonoids/pharmacology; Inhibitory Concentration 50; Micronesia; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Spectrophotometry, Infrared

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Cathepsins / Cysteine Proteinase Inhibitors / Chalcone / Moraceae Language: En Journal: J Nat Prod Year: 2002 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links