Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug.

Smee, Donald F; Bailey, Kevin W; Sidwell, Robert W

Smee, Donald F; Bailey, Kevin W; Sidwell, Robert W.

Affiliation

Smee DF; Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 84322-5600, Logan, UT 84322-5600, USA. dsmee@cc.usu.eud

Antiviral Res ; 54(2): 113-20, 2002 May.

Article in En | MEDLINE | ID: mdl-12062396

Subject(s)

Antiviral Agents/pharmacology; Cowpox virus/growth & development; Cowpox/drug therapy; Organophosphonates; Prodrugs/pharmacology; Purines/pharmacology; Animals; Area Under Curve; Body Weight; Chlorocebus aethiops; Cidofovir; Cowpox virus/metabolism; Cytosine/analogs & derivatives; Cytosine/pharmacology; Disease Models, Animal; Female; Lung/virology; Mice; Mice, Inbred BALB C; Nasal Mucosa/virology; Organophosphorus Compounds/pharmacology; Statistics, Nonparametric; Vero Cells

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Purines / Prodrugs / Cowpox / Cowpox virus / Organophosphonates Type of study: Prognostic_studies Limits: Animals Language: En Journal: Antiviral Res Year: 2002 Type: Article Affiliation country: United States

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