Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways.

Xia, Wenle; Mullin, Robert J; Keith, Barry R; Liu, Lei-Hua; Ma, Hong; Rusnak, David W; Owens, Gary; Alligood, Krystal J; Spector, Neil L

Xia, Wenle; Mullin, Robert J; Keith, Barry R; Liu, Lei-Hua; Ma, Hong; Rusnak, David W; Owens, Gary; Alligood, Krystal J; Spector, Neil L.

Affiliation

Xia W; Department of Discovery Medicine, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina, NC 27709-3398, USA.

Oncogene ; 21(41): 6255-63, 2002 Sep 12.

Article in En | MEDLINE | ID: mdl-12214266

Subject(s)

Antineoplastic Agents/pharmacology; Enzyme Inhibitors/pharmacology; Epidermal Growth Factor/metabolism; ErbB Receptors/antagonists & inhibitors; Neoplasms/drug therapy; Protein Serine-Threonine Kinases; Quinazolines/pharmacology; Receptor, ErbB-2/antagonists & inhibitors; Signal Transduction/drug effects; Antineoplastic Agents/therapeutic use; Enzyme Inhibitors/therapeutic use; Humans; Lapatinib; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Neoplasms/metabolism; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines/therapeutic use; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Signal Transduction / Protein Serine-Threonine Kinases / Receptor, ErbB-2 / Enzyme Inhibitors / Epidermal Growth Factor / ErbB Receptors / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2002 Type: Article Affiliation country: United States

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