CycloSal-BVDUMP pronucleotides: how to convert an antiviral-inactive nucleoside analogue into a bioactive compound against EBV.

Meier, Chris; Lomp, Andreas; Meerbach, Astrid; Wutzler, Peter

Meier, Chris; Lomp, Andreas; Meerbach, Astrid; Wutzler, Peter.

Affiliation

Meier C; Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, Germany. chris.meier@chemie.uni-hamburg.de

J Med Chem ; 45(23): 5157-72, 2002 Nov 07.

Article in En | MEDLINE | ID: mdl-12408726

Subject(s)

Antiviral Agents/chemical synthesis; Bromodeoxyuridine/analogs & derivatives; Bromodeoxyuridine/chemical synthesis; Deoxyuracil Nucleotides/chemical synthesis; Herpesvirus 4, Human/drug effects; Antiviral Agents/chemistry; Antiviral Agents/pharmacology; Bromodeoxyuridine/chemistry; Bromodeoxyuridine/pharmacology; Cell Division/drug effects; Cell Extracts; Deoxyuracil Nucleotides/chemistry; Deoxyuracil Nucleotides/pharmacology; Esters; Humans; Hydrolysis; Kinetics; Structure-Activity Relationship; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Bromodeoxyuridine / Herpesvirus 4, Human / Deoxyuracil Nucleotides Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Type: Article Affiliation country: Germany

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