Modulation of anxiety through blockade of anandamide hydrolysis.

Kathuria, Satish; Gaetani, Silvana; Fegley, Darren; Valiño, Fernando; Duranti, Andrea; Tontini, Andrea; Mor, Marco; Tarzia, Giorgio; La Rana, Giovanna; Calignano, Antonio; Giustino, Arcangela; Tattoli, Maria; Palmery, Maura; Cuomo, Vincenzo; Piomelli, Daniele

Kathuria, Satish; Gaetani, Silvana; Fegley, Darren; Valiño, Fernando; Duranti, Andrea; Tontini, Andrea; Mor, Marco; Tarzia, Giorgio; La Rana, Giovanna; Calignano, Antonio; Giustino, Arcangela; Tattoli, Maria; Palmery, Maura; Cuomo, Vincenzo; Piomelli, Daniele.

Affiliation

Kathuria S; Department of Pharmacology, University of California, Irvine, California, USA.

Nat Med ; 9(1): 76-81, 2003 Jan.

Article in En | MEDLINE | ID: mdl-12461523

Subject(s)

Amidohydrolases/antagonists & inhibitors; Anti-Anxiety Agents/metabolism; Anxiety/metabolism; Arachidonic Acids/metabolism; Cannabinoids/metabolism; Amidohydrolases/metabolism; Animals; Anti-Anxiety Agents/chemistry; Anti-Anxiety Agents/pharmacology; Anti-Anxiety Agents/therapeutic use; Anxiety/drug therapy; Arachidonic Acids/therapeutic use; Behavior, Animal/drug effects; Behavior, Animal/physiology; Cannabinoids/antagonists & inhibitors; Cannabinoids/therapeutic use; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Molecular Structure; Neurons/cytology; Neurons/drug effects; Neurons/metabolism; Piperidines/pharmacology; Polyunsaturated Alkamides; Pyrazoles/pharmacology; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug/metabolism; Rimonabant; Vocalization, Animal

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Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Anti-Anxiety Agents / Cannabinoids / Arachidonic Acids / Amidohydrolases Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2003 Type: Article Affiliation country: United States

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