The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

Brown, Andrew J; Goldsworthy, Susan M; Barnes, Ashley A; Eilert, Michelle M; Tcheang, Lili; Daniels, Dion; Muir, Alison I; Wigglesworth, Mark J; Kinghorn, Ian; Fraser, Neil J; Pike, Nicholas B; Strum, Jay C; Steplewski, Klaudia M; Murdock, Paul R; Holder, Julie C; Marshall, Fiona H; Szekeres, Philip G; Wilson, Shelagh; Ignar, Diane M; Foord, Steve M; Wise, Alan; Dowell, Simon J

Brown, Andrew J; Goldsworthy, Susan M; Barnes, Ashley A; Eilert, Michelle M; Tcheang, Lili; Daniels, Dion; Muir, Alison I; Wigglesworth, Mark J; Kinghorn, Ian; Fraser, Neil J; Pike, Nicholas B; Strum, Jay C; Steplewski, Klaudia M; Murdock, Paul R; Holder, Julie C; Marshall, Fiona H; Szekeres, Philip G; Wilson, Shelagh; Ignar, Diane M; Foord, Steve M; Wise, Alan; Dowell, Simon J.

Affiliation

Brown AJ; Department of 7TMR Systems Research, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom. andrew.j.brown@gsk.com

J Biol Chem ; 278(13): 11312-9, 2003 Mar 28.

Article in En | MEDLINE | ID: mdl-12496283

Subject(s)

Carboxylic Acids/pharmacology; Propionates/pharmacology; Receptors, Cell Surface/agonists; Receptors, G-Protein-Coupled; Amino Acid Sequence; Animals; DNA Primers; Humans; Immunohistochemistry; Molecular Sequence Data; Receptors, Cell Surface/metabolism; Recombinant Proteins/drug effects; Recombinant Proteins/metabolism; Xenopus laevis

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Collection: 01-internacional Database: MEDLINE Main subject: Propionates / Carboxylic Acids / Receptors, Cell Surface / Receptors, G-Protein-Coupled Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2003 Type: Article Affiliation country: United kingdom

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