The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.

Briscoe, Celia P; Tadayyon, Mohammad; Andrews, John L; Benson, William G; Chambers, Jon K; Eilert, Michelle M; Ellis, Catherine; Elshourbagy, Nabil A; Goetz, Aaron S; Minnick, Dana T; Murdock, Paul R; Sauls, Howard R; Shabon, Usman; Spinage, Lisa D; Strum, Jay C; Szekeres, Philip G; Tan, Kong B; Way, James M; Ignar, Diane M; Wilson, Shelagh; Muir, Alison I

Briscoe, Celia P; Tadayyon, Mohammad; Andrews, John L; Benson, William G; Chambers, Jon K; Eilert, Michelle M; Ellis, Catherine; Elshourbagy, Nabil A; Goetz, Aaron S; Minnick, Dana T; Murdock, Paul R; Sauls, Howard R; Shabon, Usman; Spinage, Lisa D; Strum, Jay C; Szekeres, Philip G; Tan, Kong B; Way, James M; Ignar, Diane M; Wilson, Shelagh; Muir, Alison I.

Affiliation

Briscoe CP; Department of Metabolic Diseases, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA. cpb15172@gsk.com

J Biol Chem ; 278(13): 11303-11, 2003 Mar 28.

Article in En | MEDLINE | ID: mdl-12496284

Subject(s)

Fatty Acids/pharmacology; Receptors, Cell Surface/drug effects; Receptors, Cell Surface/metabolism; Receptors, G-Protein-Coupled; Animals; Base Sequence; Calcium/metabolism; Cell Line; Cloning, Molecular; Cricetinae; DNA Primers; Fatty Acids/genetics; Humans; In Situ Hybridization; Luciferases/genetics; Molecular Sequence Data; Receptors, Cell Surface/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Cell Surface / Receptors, G-Protein-Coupled / Fatty Acids Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2003 Type: Article Affiliation country: United States

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