The age-dependent efficacy of polyadenylic-polyuridylic acid therapy upon the development of spontaneous leukemia in AKR mice.
Cancer Res
; 36(3): 1172-5, 1976 Mar.
Article
in En
| MEDLINE
| ID: mdl-1253174
ABSTRACT
The synthetic double-stranded polynucleotide, polyadenylic-polyuridylic acid, has been shown to increase the long-term survival of AKR mice. In order to determine whether this effect was age dependent, polyadenylic-polyuridylic acid was administered to AKR mice starting at 2, 4, 6, or 8 months of age. The best therapeutic effect was achieved when polyadenylic-polyuridylic acid treatments were begun at 2 months of age, and there was no beneficial effect when begun at 8 months of age.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, Lymphoid
/
Age Factors
/
Poly A-U
Limits:
Animals
Language:
En
Journal:
Cancer Res
Year:
1976
Type:
Article