Enhancing risk of ethanol on MeIQx-induced rat hepatocarcinogenesis is accompanied with increased levels of cellular proliferation and oxidative stress.

Karim, M Rezaul; Wanibuchi, Hideki; Wei, Min; Morimura, Keiichirou; Salim, Elsayed I; Fukushima, Shoji

Karim, M Rezaul; Wanibuchi, Hideki; Wei, Min; Morimura, Keiichirou; Salim, Elsayed I; Fukushima, Shoji.

Affiliation

Karim MR; Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan.

Cancer Lett ; 192(1): 37-47, 2003 Mar 20.

Article in En | MEDLINE | ID: mdl-12637151

Subject(s)

Carcinoma, Hepatocellular/chemically induced; Carcinoma, Hepatocellular/pathology; Deoxyguanosine/analogs & derivatives; Ethanol/adverse effects; Ethanol/pharmacology; Oxidative Stress/drug effects; Quinolines/pharmacology; 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Division/drug effects; DNA, Neoplasm/metabolism; DNA-Formamidopyrimidine Glycosylase; Deoxyguanosine/metabolism; Liver/drug effects; Liver/pathology; Male; N-Glycosyl Hydrolases/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Rats, Inbred F344; Risk Factors; Time Factors; Transaminases/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Carcinoma, Hepatocellular / Oxidative Stress / Deoxyguanosine / Ethanol Type of study: Etiology_studies / Risk_factors_studies Limits: Animals Language: En Journal: Cancer Lett Year: 2003 Type: Article Affiliation country: Japan

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