Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease.

Kaur, Deepinder; Yantiri, Ferda; Rajagopalan, Subramanian; Kumar, Jyothi; Mo, Jun Qin; Boonplueang, Rapee; Viswanath, Veena; Jacobs, Russell; Yang, Lichuan; Beal, M Flint; DiMonte, Dino; Volitaskis, Irene; Ellerby, Lisa; Cherny, Robert A; Bush, Ashley I; Andersen, Julie K

Kaur, Deepinder; Yantiri, Ferda; Rajagopalan, Subramanian; Kumar, Jyothi; Mo, Jun Qin; Boonplueang, Rapee; Viswanath, Veena; Jacobs, Russell; Yang, Lichuan; Beal, M Flint; DiMonte, Dino; Volitaskis, Irene; Ellerby, Lisa; Cherny, Robert A; Bush, Ashley I; Andersen, Julie K.

Affiliation

Kaur D; Buck Institute for Age Research, Novato, CA 94945, USA.

Neuron ; 37(6): 899-909, 2003 Mar 27.

Article in En | MEDLINE | ID: mdl-12670420

Subject(s)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Ferritins/genetics; Iron Chelating Agents/therapeutic use; Iron/metabolism; Parkinson Disease, Secondary/prevention & control; Parkinson Disease/drug therapy; 3,4-Dihydroxyphenylacetic Acid/analysis; Animals; Blotting, Western; Cell Death; Clioquinol/therapeutic use; Dopamine/analysis; Ferritins/metabolism; Gene Expression; Genetic Therapy; Homovanillic Acid/analysis; Humans; Immunohistochemistry; Iron Chelating Agents/metabolism; Mice; Mice, Transgenic; Oxidative Stress; Parkinson Disease/pathology; Parkinson Disease, Secondary/chemically induced; Promoter Regions, Genetic; Rats; Substantia Nigra/chemistry; Substantia Nigra/metabolism; Substantia Nigra/pathology; Tyrosine 3-Monooxygenase/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Parkinson Disease, Secondary / 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Iron Chelating Agents / Ferritins / Iron Limits: Animals / Humans Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2003 Type: Article Affiliation country: United States

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