Oxidative stress-induced homologous recombination as a novel mechanism for phenytoin-initiated toxicity.

Winn, Louise M; Kim, Perry M; Nickoloff, Jac A

Winn, Louise M; Kim, Perry M; Nickoloff, Jac A.

Affiliation

Winn LM; Department of Pharmacology and Toxicology and School of Environmental Studies, Queen's University, Kingston, ON, Canada. winnl@biology.queensu.ca

J Pharmacol Exp Ther ; 306(2): 523-7, 2003 Aug.

Article in En | MEDLINE | ID: mdl-12730361

Subject(s)

DNA/drug effects; Oxidative Stress/physiology; Phenytoin/pharmacology; Recombination, Genetic/drug effects; Recombination, Genetic/physiology; Animals; CHO Cells; Cricetinae; DNA/metabolism; DNA Damage; Drug-Related Side Effects and Adverse Reactions; Female; Oxidation-Reduction/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Phenytoin / Recombination, Genetic / DNA / Oxidative Stress Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2003 Type: Article Affiliation country: Canada

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