Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.

Most, Patrick; Remppis, Andrew; Pleger, Sven T; Löffler, Eva; Ehlermann, Philipp; Bernotat, Juliane; Kleuss, Christiane; Heierhorst, Jörg; Ruiz, Patricia; Witt, Henning; Karczewski, Peter; Mao, Lan; Rockman, Howard A; Duncan, Sandra J; Katus, Hugo A; Koch, Walter J

Most, Patrick; Remppis, Andrew; Pleger, Sven T; Löffler, Eva; Ehlermann, Philipp; Bernotat, Juliane; Kleuss, Christiane; Heierhorst, Jörg; Ruiz, Patricia; Witt, Henning; Karczewski, Peter; Mao, Lan; Rockman, Howard A; Duncan, Sandra J; Katus, Hugo A; Koch, Walter J.

Affiliation

Most P; Medizinische Universitätsklinik und Poliklinik III, Universität zu Heidelberg, 69115 Heidelberg.

J Biol Chem ; 278(36): 33809-17, 2003 Sep 05.

Article in En | MEDLINE | ID: mdl-12777394

Subject(s)

Calcium-Binding Proteins/genetics; Calcium-Binding Proteins/physiology; Mice, Transgenic; Myocardial Contraction; Myocardium/metabolism; Ryanodine Receptor Calcium Release Channel/metabolism; Adrenergic beta-Agonists/pharmacology; Animals; Blotting, Northern; Blotting, Western; Calcium/metabolism; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Echocardiography; Isoproterenol/pharmacology; Kinetics; Mice; Precipitin Tests; Protein Binding; Receptors, Adrenergic, beta/metabolism; S100 Proteins; Sarcoplasmic Reticulum/metabolism; Signal Transduction; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Calcium-Binding Proteins / Mice, Transgenic / Ryanodine Receptor Calcium Release Channel / Myocardial Contraction / Myocardium Limits: Animals Language: En Journal: J Biol Chem Year: 2003 Type: Article

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