Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapine-induced skin rash in the rat.

Shenton, Jacintha M; Teranishi, Munehiro; Abu-Asab, Mones S; Yager, Julie A; Uetrecht, Jack P

Shenton, Jacintha M; Teranishi, Munehiro; Abu-Asab, Mones S; Yager, Julie A; Uetrecht, Jack P.

Affiliation

Shenton JM; Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

Chem Res Toxicol ; 16(9): 1078-89, 2003 Sep.

Article in En | MEDLINE | ID: mdl-12971795

Subject(s)

Disease Models, Animal; Drug Eruptions/etiology; Exanthema/chemically induced; Nevirapine/adverse effects; Administration, Oral; Animals; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes/immunology; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical/methods; Exanthema/pathology; Exanthema/physiopathology; Female; Food; Forecasting; Hepatomegaly/chemically induced; Hepatomegaly/complications; Hepatomegaly/pathology; Liver/drug effects; Liver/pathology; Liver/ultrastructure; Macrophages/immunology; Male; Mice; Mice, Inbred Strains; Nevirapine/administration & dosage; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Skin/drug effects; Skin/pathology; Skin/ultrastructure; Spleen/cytology; Spleen/physiopathology; Spleen/transplantation; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Drug Eruptions / Nevirapine / Disease Models, Animal / Exanthema Type of study: Prognostic_studies Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2003 Type: Article Affiliation country: Canada

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