Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.

Lau, C K; Bélanger, P C; Dufresne, C; Scheigetz, J; Therien, M; Fitzsimmons, B; Young, R N; Ford-Hutchinson, A W; Riendeau, D; Denis, D

Lau, C K; Bélanger, P C; Dufresne, C; Scheigetz, J; Therien, M; Fitzsimmons, B; Young, R N; Ford-Hutchinson, A W; Riendeau, D; Denis, D.

Affiliation

Lau CK; Department of Medicinal Chemistry, Merck Frosst Centre For Therapeutic Research, Pointe Claire-Dorval, Quebec, Canada.

J Med Chem ; 35(7): 1299-318, 1992 Apr 03.

Article in En | MEDLINE | ID: mdl-1313879

Subject(s)

Arachidonate 5-Lipoxygenase/metabolism; Benzofurans/chemical synthesis; Lipoxygenase Inhibitors/chemical synthesis; Animals; Benzofurans/chemistry; Benzofurans/pharmacokinetics; Benzofurans/pharmacology; Biological Availability; Bronchoconstriction/drug effects; Dogs; Humans; Leukocytes, Mononuclear/enzymology; Leukotriene B4/biosynthesis; Lipoxygenase Inhibitors/pharmacology; Male; Methemoglobin/metabolism; Microsomes, Liver/metabolism; Molecular Structure; Rats; Rats, Inbred Strains; Saimiri; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Benzofurans / Arachidonate 5-Lipoxygenase / Lipoxygenase Inhibitors Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1992 Type: Article Affiliation country: Canada

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