Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.

Dou, Huanyu; Birusingh, Kevin; Faraci, Jill; Gorantla, Santhi; Poluektova, Larisa Y; Maggirwar, Sanjay B; Dewhurst, Stephen; Gelbard, Harris A; Gendelman, Howard E

Dou, Huanyu; Birusingh, Kevin; Faraci, Jill; Gorantla, Santhi; Poluektova, Larisa Y; Maggirwar, Sanjay B; Dewhurst, Stephen; Gelbard, Harris A; Gendelman, Howard E.

Affiliation

Dou H; Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198-5215, USA.

J Neurosci ; 23(27): 9162-70, 2003 Oct 08.

Article in En | MEDLINE | ID: mdl-14534250

Subject(s)

AIDS Dementia Complex/drug therapy; HIV-1; Neurons/drug effects; Neuroprotective Agents/therapeutic use; Valproic Acid/therapeutic use; AIDS Dementia Complex/pathology; AIDS Dementia Complex/physiopathology; Animals; Basal Ganglia/pathology; Basal Ganglia/virology; Biomarkers/analysis; Cell Differentiation; Cells, Cultured; Coculture Techniques; Disease Models, Animal; HIV Core Protein p24/analysis; HIV Core Protein p24/biosynthesis; HIV Envelope Protein gp120/toxicity; HIV-1/genetics; HIV-1/growth & development; HIV-1/isolation & purification; Humans; Macrophages/pathology; Macrophages/virology; Male; Mice; Mice, SCID; Monocytes/cytology; Monocytes/drug effects; Neuroglia/drug effects; Neuroglia/pathology; Neurons/pathology; Phosphorylation/drug effects; RNA, Viral/analysis; RNA, Viral/biosynthesis; Rats; Rats, Sprague-Dawley; tau Proteins/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Valproic Acid / AIDS Dementia Complex / HIV-1 / Neuroprotective Agents / Neurons Language: En Journal: J Neurosci Year: 2003 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google