GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.

Moore, Darren J; Murdock, Paul R; Watson, Jeannette M; Faull, Richard L M; Waldvogel, Henry J; Szekeres, Philip G; Wilson, Shelagh; Freeman, Katie B; Emson, Piers C

Moore, Darren J; Murdock, Paul R; Watson, Jeannette M; Faull, Richard L M; Waldvogel, Henry J; Szekeres, Philip G; Wilson, Shelagh; Freeman, Katie B; Emson, Piers C.

Affiliation

Moore DJ; Neurobiology Programme, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK. dmoore20@jhmi.edu

Brain Res Mol Brain Res ; 118(1-2): 10-23, 2003 Oct 21.

Article in En | MEDLINE | ID: mdl-14559350

Subject(s)

Astrocytes/metabolism; Brain/metabolism; Leukocytes/metabolism; Receptors, G-Protein-Coupled/metabolism; Receptors, Immunologic/metabolism; Receptors, Purinergic P2/metabolism; Animals; Astrocytes/immunology; Brain/immunology; Cell Line; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism; Gene Expression Regulation/drug effects; Gene Expression Regulation/immunology; Glucose/immunology; Humans; Immunohistochemistry; Leukocytes/immunology; Lipopolysaccharides/immunology; Male; Neuroimmunomodulation/immunology; Protein Subunits/genetics; Protein Subunits/metabolism; RNA, Messenger/metabolism; Rats; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/immunology; Receptors, Immunologic/genetics; Receptors, Immunologic/immunology; Receptors, Purinergic P2/genetics; Receptors, Purinergic P2/immunology; Receptors, Purinergic P2Y; Up-Regulation/immunology; Uridine Diphosphate/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Receptors, Immunologic / Astrocytes / Receptors, Purinergic P2 / Receptors, G-Protein-Coupled / Leukocytes Limits: Animals / Humans / Male Language: En Journal: Brain Res Mol Brain Res Journal subject: BIOLOGIA MOLECULAR / CEREBRO Year: 2003 Type: Article Affiliation country: United kingdom

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