IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha.

Maeda, Shin; Chang, Lufen; Li, Zhi-Wei; Luo, Jun-Li; Leffert, Hyam; Karin, Michael

Maeda, Shin; Chang, Lufen; Li, Zhi-Wei; Luo, Jun-Li; Leffert, Hyam; Karin, Michael.

Affiliation

Maeda S; Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA

Immunity ; 19(5): 725-37, 2003 Nov.

Article in En | MEDLINE | ID: mdl-14614859

Subject(s)

Apoptosis/physiology; Protein Serine-Threonine Kinases/metabolism; Tumor Necrosis Factor-alpha/metabolism; Animals; Antigens, CD/metabolism; Concanavalin A/metabolism; I-kappa B Kinase; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides/metabolism; Liver/pathology; Liver/physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases/metabolism; Protein Serine-Threonine Kinases/genetics; Receptors, Tumor Necrosis Factor/metabolism; Receptors, Tumor Necrosis Factor, Type II; T-Lymphocytes/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Protein Serine-Threonine Kinases / Apoptosis Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2003 Type: Article Affiliation country: United States

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