Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.

Stearns, Vered; Johnson, Michael D; Rae, James M; Morocho, Alan; Novielli, Antonella; Bhargava, Pankaj; Hayes, Daniel F; Desta, Zeruesenay; Flockhart, David A

Stearns, Vered; Johnson, Michael D; Rae, James M; Morocho, Alan; Novielli, Antonella; Bhargava, Pankaj; Hayes, Daniel F; Desta, Zeruesenay; Flockhart, David A.

Affiliation

Stearns V; The Breast Cancer Program, Department of Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA.

J Natl Cancer Inst ; 95(23): 1758-64, 2003 Dec 03.

Article in En | MEDLINE | ID: mdl-14652237

Subject(s)

Antineoplastic Agents, Hormonal/pharmacokinetics; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics; Breast Neoplasms/blood; Breast Neoplasms/drug therapy; Paroxetine/pharmacokinetics; Selective Estrogen Receptor Modulators/pharmacokinetics; Selective Serotonin Reuptake Inhibitors/pharmacokinetics; Tamoxifen/analogs & derivatives; Tamoxifen/pharmacokinetics; Adult; Aged; Antineoplastic Agents, Hormonal/administration & dosage; Antineoplastic Agents, Hormonal/blood; Antineoplastic Combined Chemotherapy Protocols/blood; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Breast Neoplasms/enzymology; Chemotherapy, Adjuvant; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors/pharmacology; Female; Humans; Microsomes, Liver/metabolism; Middle Aged; Paroxetine/administration & dosage; Paroxetine/blood; Prospective Studies; Selective Estrogen Receptor Modulators/administration & dosage; Selective Estrogen Receptor Modulators/blood; Selective Serotonin Reuptake Inhibitors/administration & dosage; Selective Serotonin Reuptake Inhibitors/blood; Tamoxifen/administration & dosage; Tamoxifen/blood; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Tamoxifen / Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Selective Serotonin Reuptake Inhibitors / Paroxetine / Antineoplastic Agents, Hormonal / Selective Estrogen Receptor Modulators Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: J Natl Cancer Inst Year: 2003 Type: Article Affiliation country: United States

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