S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole.

Millan, Mark J; Di Cara, Benjamin; Hill, Michael; Jackson, Michael; Joyce, Jeffrey N; Brotchie, Jonathan; McGuire, Steve; Crossman, Alan; Smith, Lance; Jenner, Peter; Gobert, Alain; Peglion, Jean-Louis; Brocco, Mauricette

Millan, Mark J; Di Cara, Benjamin; Hill, Michael; Jackson, Michael; Joyce, Jeffrey N; Brotchie, Jonathan; McGuire, Steve; Crossman, Alan; Smith, Lance; Jenner, Peter; Gobert, Alain; Peglion, Jean-Louis; Brocco, Mauricette.

Affiliation

Millan MJ; Institut de Recherches Servier, Centre de Recherches de Croissy, Psychopharmacology Department, Paris, France. mark.millan@fr.netgrs.com

J Pharmacol Exp Ther ; 309(3): 921-35, 2004 Jun.

Article in En | MEDLINE | ID: mdl-14978195

Subject(s)

Dopamine Agonists/therapeutic use; Dyskinesias/drug therapy; Indoles/therapeutic use; MPTP Poisoning/drug therapy; Oxazines/therapeutic use; Acetylcholine/metabolism; Animals; Callithrix; Cells, Cultured; Disease Models, Animal; Dopamine Agonists/pharmacology; Dopamine Antagonists/pharmacology; Drug Interactions; Dyskinesias/etiology; Electrophysiology; Extracellular Space; Humans; Hypokinesia/chemically induced; Hypokinesia/drug therapy; Levodopa/pharmacology; Levodopa/therapeutic use; Male; Motor Activity/drug effects; Neuroprotective Agents/pharmacology; Neuroprotective Agents/therapeutic use; Oxazines/pharmacology; Rats; Rats, Wistar; Receptors, Dopamine D2/agonists; Receptors, Dopamine D2/metabolism; Receptors, Dopamine D3; Reserpine/pharmacology; Rotation

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Collection: 01-internacional Database: MEDLINE Main subject: Oxazines / Dopamine Agonists / MPTP Poisoning / Dyskinesias / Indoles Type of study: Etiology_studies Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2004 Type: Article Affiliation country: France

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