Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.

Douangamath, Alice; Dale, Glenn E; D'Arcy, Allan; Almstetter, Michael; Eckl, Robert; Frutos-Hoener, Annabelle; Henkel, Bernd; Illgen, Katrin; Nerdinger, Sven; Schulz, Henk; Mac Sweeney, Aengus; MacSweeney, Aengus; Thormann, Michael; Treml, Andreas; Pierau, Sabine; Wadman, Sjoerd; Oefner, Christian

Douangamath, Alice; Dale, Glenn E; D'Arcy, Allan; Almstetter, Michael; Eckl, Robert; Frutos-Hoener, Annabelle; Henkel, Bernd; Illgen, Katrin; Nerdinger, Sven; Schulz, Henk; Mac Sweeney, Aengus; MacSweeney, Aengus; Thormann, Michael; Treml, Andreas; Pierau, Sabine; Wadman, Sjoerd; Oefner, Christian.

Affiliation

Douangamath A; Morphochem AG, WRO-1055/388, Schwarzwaldallee 215, CH-4058 Basel, Switzerland.

J Med Chem ; 47(6): 1325-8, 2004 Mar 11.

Article in En | MEDLINE | ID: mdl-14998322

Subject(s)

Amines/chemistry; Aminopeptidases/antagonists & inhibitors; Aminopeptidases/chemistry; Ketones/chemistry; Pyridines/chemistry; Staphylococcus aureus/enzymology; Thiazoles/chemistry; Binding Sites; Crystallography, X-Ray; Cyclopropanes/chemistry; Methionyl Aminopeptidases; Models, Molecular; Molecular Structure

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Staphylococcus aureus / Thiazoles / Amines / Aminopeptidases / Ketones Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Type: Article Affiliation country: Switzerland

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