Identification of purine inhibitors of phosphodiesterase 7 (PDE7).

Pitts, William J; Vaccaro, Wayne; Huynh, Tram; Leftheris, Katerina; Roberge, Jacques Y; Barbosa, Joseph; Guo, Junqing; Brown, Baerbel; Watson, Andrew; Donaldson, Karen; Starling, Gary C; Kiener, Peter A; Poss, Michael A; Dodd, John H; Barrish, Joel C

Pitts, William J; Vaccaro, Wayne; Huynh, Tram; Leftheris, Katerina; Roberge, Jacques Y; Barbosa, Joseph; Guo, Junqing; Brown, Baerbel; Watson, Andrew; Donaldson, Karen; Starling, Gary C; Kiener, Peter A; Poss, Michael A; Dodd, John H; Barrish, Joel C.

Affiliation

Pitts WJ; Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. pittsw@bms.com

Bioorg Med Chem Lett ; 14(11): 2955-8, 2004 Jun 07.

Article in En | MEDLINE | ID: mdl-15125967

Subject(s)

3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors; Purines/chemical synthesis; Purines/pharmacology; Binding Sites; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 7; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Humans; Inhibitory Concentration 50; Ligands; Structure-Activity Relationship; T-Lymphocytes/enzymology

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Collection: 01-internacional Database: MEDLINE Main subject: Purines / 3',5'-Cyclic-AMP Phosphodiesterases Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Type: Article Affiliation country: United States

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