Short-term in vitro and in vivo analyses for assessing the tumor-promoting potentials of cigarette smoke condensates.

Curtin, Geoffrey M; Hanausek, Margaret; Walaszek, Zbigniew; Mosberg, Arnold T; Slaga, Thomas J

Curtin, Geoffrey M; Hanausek, Margaret; Walaszek, Zbigniew; Mosberg, Arnold T; Slaga, Thomas J.

Affiliation

Curtin GM; Research and Development, RJ Reynolds Tobacco Company, Winston-Salem, NC 27102, USA. curting@rjrt.com

Toxicol Sci ; 81(1): 14-25, 2004 Sep.

Article in En | MEDLINE | ID: mdl-15159522

Subject(s)

Carcinogens/toxicity; Smoke/adverse effects; Adenosine Triphosphate/metabolism; Animals; Body Weight/drug effects; Carcinogenicity Tests; Cell Proliferation/drug effects; Cytochromes c/metabolism; DNA Adducts/drug effects; Genes, ras/drug effects; Hydroxyl Radical/metabolism; Hyperplasia/chemically induced; Hyperplasia/pathology; Inflammation/chemically induced; Inflammation/pathology; Leukocytes/pathology; Luminescent Measurements; Mice; Mice, Inbred SENCAR; Oxidation-Reduction; Oxidative Stress/drug effects; Peroxidase/metabolism; Salicylates/metabolism; Skin/pathology; Skin Neoplasms/chemically induced; Skin Neoplasms/pathology; Superoxides/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Smoke / Carcinogens Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2004 Type: Article Affiliation country: United States

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