Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2.

Liang, Min; Liang, Yao-Yun; Wrighton, Katharine; Ungermannova, Dana; Wang, Xiao-Ping; Brunicardi, F Charles; Liu, Xuedong; Feng, Xin-Hua; Lin, Xia

Liang, Min; Liang, Yao-Yun; Wrighton, Katharine; Ungermannova, Dana; Wang, Xiao-Ping; Brunicardi, F Charles; Liu, Xuedong; Feng, Xin-Hua; Lin, Xia.

Affiliation

Liang M; Department of Molecular & Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Room 137D, Houston, TX 77030, USA.

Mol Cell Biol ; 24(17): 7524-37, 2004 Sep.

Article in En | MEDLINE | ID: mdl-15314162

Subject(s)

DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Neoplasms/metabolism; S-Phase Kinase-Associated Proteins/metabolism; Trans-Activators/genetics; Trans-Activators/metabolism; Ubiquitin-Protein Ligases/metabolism; Ubiquitin/metabolism; Amino Acid Motifs; Animals; Cell Line; Cysteine Endopeptidases/metabolism; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases/metabolism; Multienzyme Complexes/metabolism; Neoplasms/genetics; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; RNA Interference; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; S-Phase Kinase-Associated Proteins/genetics; Signal Transduction/physiology; Smad4 Protein; Ubiquitin-Protein Ligases/genetics; p38 Mitogen-Activated Protein Kinases

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trans-Activators / Ubiquitin / Ubiquitin-Protein Ligases / S-Phase Kinase-Associated Proteins / DNA-Binding Proteins / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Biol Year: 2004 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google