Evolution of glutamate dehydrogenase regulation of insulin homeostasis is an example of molecular exaptation.

Allen, Aron; Kwagh, Jae; Fang, Jie; Stanley, Charles A; Smith, Thomas J

Allen, Aron; Kwagh, Jae; Fang, Jie; Stanley, Charles A; Smith, Thomas J.

Affiliation

Allen A; The Donald Danforth Plant Science Center, 975 North Warson Road, St. Louis, Missouri 63132, USA.

Biochemistry ; 43(45): 14431-43, 2004 Nov 16.

Article in En | MEDLINE | ID: mdl-15533048

Subject(s)

Adenosine Diphosphate/analogs & derivatives; Evolution, Molecular; Glutamate Dehydrogenase/chemistry; Homeostasis; Insulin/metabolism; Adenosine Diphosphate/chemistry; Adenosine Diphosphate/metabolism; Alanine/genetics; Allosteric Regulation/genetics; Animals; Arginine/genetics; Cattle; Deamination; Glutamate Dehydrogenase/antagonists & inhibitors; Glutamate Dehydrogenase/genetics; Glutamate Dehydrogenase/metabolism; Homeostasis/genetics; Humans; Insulin Secretion; Kinetics; Lipid Peroxidation; Palmitoyl Coenzyme A/chemistry; Protein Binding; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tetrahymena thermophila/enzymology; Tetrahymena thermophila/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Diphosphate / Evolution, Molecular / Glutamate Dehydrogenase / Homeostasis / Insulin Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2004 Type: Article Affiliation country: United States

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