Pathologic changes induced by phospholipase A2 isolated from the venom of Collett's snake, Pseudechis colletti: a light and electron microscopic study.
Toxicon
; 30(2): 171-85, 1992 Feb.
Article
in En
| MEDLINE
| ID: mdl-1557787
ABSTRACT
Pseudechis colletti is an Australian elapid snake with a range limited to central Queensland, Australia. The venom of this snake, as well as that of several other Australian elapids, has been shown to contain a phospholipase A2 (PLA2) which can cause a marked myoglobinuria in mice. Few studies have described the histopathologic and ultrastructural changes that result from myotoxic PLA2-induced damage. Our investigation demonstrated that the isolated PLA2 induced myodegeneration and necrosis in myocardium in a dose-related manner, with subsequent myoglobinuria and myoglobinuric nephropathy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phospholipases A
/
Elapid Venoms
/
Muscles
Limits:
Animals
Language:
En
Journal:
Toxicon
Year:
1992
Type:
Article