Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies.

Spector, Neil L; Xia, Wenle; Burris, Howard; Hurwitz, Herbert; Dees, E Claire; Dowlati, Afshin; O'Neil, Bert; Overmoyer, Beth; Marcom, Paul K; Blackwell, Kimberly L; Smith, Deborah A; Koch, Kevin M; Stead, Andrew; Mangum, Steven; Ellis, Matthew J; Liu, Leihua; Man, Albert K; Bremer, Troy M; Harris, Jennifer; Bacus, Sarah

Spector, Neil L; Xia, Wenle; Burris, Howard; Hurwitz, Herbert; Dees, E Claire; Dowlati, Afshin; O'Neil, Bert; Overmoyer, Beth; Marcom, Paul K; Blackwell, Kimberly L; Smith, Deborah A; Koch, Kevin M; Stead, Andrew; Mangum, Steven; Ellis, Matthew J; Liu, Leihua; Man, Albert K; Bremer, Troy M; Harris, Jennifer; Bacus, Sarah.

Affiliation

Spector NL; Department of Discovery Medicine and Clinical Pharmacology, GlaxoSmithKline, Five Moore Dr, Research Triangle Park, NC 27709-3398, USA. Neil.L.Spector@gsk.com

J Clin Oncol ; 23(11): 2502-12, 2005 Apr 10.

Article in En | MEDLINE | ID: mdl-15684311

Subject(s)

ErbB Receptors/biosynthesis; Neoplasms/drug therapy; Quinazolines/pharmacology; Quinazolines/therapeutic use; Receptor, ErbB-2/biosynthesis; Adult; Aged; Aged, 80 and over; Apoptosis; Biomarkers, Tumor/analysis; Cell Survival; Dose-Response Relationship, Drug; Endpoint Determination; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lapatinib; Male; Middle Aged; Neoplasms/physiopathology; Quinazolines/administration & dosage; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Receptor, ErbB-2 / ErbB Receptors / Neoplasms Type of study: Clinical_trials Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Clin Oncol Year: 2005 Type: Article Affiliation country: United States

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