A randomized, double-blind, placebo-controlled trial of CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, in patients with corticosteroid-dependent Crohn's disease.

Feagan, B G; Sandborn, W J; Baker, J P; Cominelli, F; Sutherland, L R; Elson, C O; Salzberg, B A; Archambault, A; Bernstein, C N; Lichtenstein, G R; Heath, P K; Cameron, S; Hanauer, S B

Feagan, B G; Sandborn, W J; Baker, J P; Cominelli, F; Sutherland, L R; Elson, C O; Salzberg, B A; Archambault, A; Bernstein, C N; Lichtenstein, G R; Heath, P K; Cameron, S; Hanauer, S B.

Affiliation

Feagan BG; The John P Robarts Research Institute, University of Western Ontario, London, ON, Canada. bfeagan@robarts.ca

Aliment Pharmacol Ther ; 21(4): 373-84, 2005 Feb 15.

Article in En | MEDLINE | ID: mdl-15709987

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Antibodies, Monoclonal/therapeutic use; Crohn Disease/drug therapy; Gastrointestinal Agents/therapeutic use; Adult; Anti-Inflammatory Agents/administration & dosage; Anti-Inflammatory Agents/adverse effects; Antibodies, Monoclonal/adverse effects; Budesonide/administration & dosage; Crohn Disease/pathology; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Prednisolone/administration & dosage; Quality of Life; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Gastrointestinal Agents / Crohn Disease / Anti-Inflammatory Agents, Non-Steroidal / Antibodies, Monoclonal Type of study: Clinical_trials Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Aliment Pharmacol Ther Journal subject: FARMACOLOGIA / GASTROENTEROLOGIA / TERAPIA POR MEDICAMENTOS Year: 2005 Type: Article Affiliation country: Canada

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