Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

Tan, Ting-Ting; Degenhardt, Kurt; Nelson, Deirdre A; Beaudoin, Brian; Nieves-Neira, Wilberto; Bouillet, Philippe; Villunger, Andreas; Adams, Jerry M; White, Eileen

Tan, Ting-Ting; Degenhardt, Kurt; Nelson, Deirdre A; Beaudoin, Brian; Nieves-Neira, Wilberto; Bouillet, Philippe; Villunger, Andreas; Adams, Jerry M; White, Eileen.

Affiliation

Tan TT; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA.

Cancer Cell ; 7(3): 227-38, 2005 Mar.

Article in En | MEDLINE | ID: mdl-15766661

Subject(s)

Antineoplastic Agents, Phytogenic/therapeutic use; Apoptosis/physiology; Carrier Proteins/metabolism; Membrane Proteins/metabolism; Neoplasms, Glandular and Epithelial/drug therapy; Neoplasms, Glandular and Epithelial/metabolism; Paclitaxel/therapeutic use; Proto-Oncogene Proteins/metabolism; Animals; Antineoplastic Agents, Phytogenic/metabolism; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Boronic Acids/therapeutic use; Bortezomib; Carrier Proteins/genetics; Cell Line; Drug Resistance, Neoplasm; Drug Therapy, Combination; Gene Expression Regulation; Genes, ras; Humans; MAP Kinase Signaling System/physiology; Membrane Proteins/genetics; Mice; Mice, Knockout; Paclitaxel/metabolism; Protease Inhibitors/therapeutic use; Proteasome Endopeptidase Complex/metabolism; Proteasome Inhibitors; Proto-Oncogene Proteins/genetics; Pyrazines/therapeutic use; Tumor Suppressor Protein p53/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Carrier Proteins / Proto-Oncogene Proteins / Paclitaxel / Apoptosis / Neoplasms, Glandular and Epithelial / Membrane Proteins / Antineoplastic Agents, Phytogenic Limits: Animals / Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2005 Type: Article Affiliation country: United States

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