Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.

Kempson, James; Pitts, William J; Barbosa, Joseph; Guo, Junqing; Omotoso, Omonike; Watson, Andrew; Stebbins, Karen; Starling, Gary C; Dodd, John H; Barrish, Joel C; Felix, Raymond; Fischer, Karl

Kempson, James; Pitts, William J; Barbosa, Joseph; Guo, Junqing; Omotoso, Omonike; Watson, Andrew; Stebbins, Karen; Starling, Gary C; Dodd, John H; Barrish, Joel C; Felix, Raymond; Fischer, Karl.

Affiliation

Kempson J; Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. james.kempson@bms.com

Bioorg Med Chem Lett ; 15(7): 1829-33, 2005 Apr 01.

Article in En | MEDLINE | ID: mdl-15780616

Subject(s)

3',5'-Cyclic-AMP Phosphodiesterases/metabolism; Isoenzymes/metabolism; Phosphodiesterase Inhibitors/chemical synthesis; Pyrimidines/chemistry; 3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 7; Humans; Inhibitory Concentration 50; Isoenzymes/antagonists & inhibitors; Phosphodiesterase Inhibitors/pharmacology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Pyrimidines / 3',5'-Cyclic-AMP Phosphodiesterases / Isoenzymes Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2005 Type: Article Affiliation country: United States

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