Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.

Saulnier, Mark G; Balasubramanian, Balu N; Long, Byron H; Frennesson, David B; Ruediger, Edward; Zimmermann, Kurt; Eummer, Jeffrey T; St Laurent, Denis R; Stoffan, Karen M; Naidu, B Narasimhulu; Mahler, Mikael; Beaulieu, Francis; Bachand, Carol; Lee, Frank Y; Fairchild, Craig R; Stadnick, Linda K; Rose, William C; Solomon, Carola; Wong, Henry; Martel, Alain; Wright, John J; Kramer, Robert; Langley, David R; Vyas, Dolatrai M

Saulnier, Mark G; Balasubramanian, Balu N; Long, Byron H; Frennesson, David B; Ruediger, Edward; Zimmermann, Kurt; Eummer, Jeffrey T; St Laurent, Denis R; Stoffan, Karen M; Naidu, B Narasimhulu; Mahler, Mikael; Beaulieu, Francis; Bachand, Carol; Lee, Frank Y; Fairchild, Craig R; Stadnick, Linda K; Rose, William C; Solomon, Carola; Wong, Henry; Martel, Alain; Wright, John J; Kramer, Robert; Langley, David R; Vyas, Dolatrai M.

Affiliation

Saulnier MG; The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. Mark.Saulnier@bms.com

J Med Chem ; 48(7): 2258-61, 2005 Apr 07.

Article in En | MEDLINE | ID: mdl-15801816

Subject(s)

Antineoplastic Agents/chemical synthesis; Camptothecin/analogs & derivatives; Camptothecin/pharmacology; Carbazoles/chemical synthesis; Glucosides/chemical synthesis; Indoles/chemical synthesis; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Carbazoles/chemistry; Carbazoles/pharmacology; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glucosides/chemistry; Glucosides/pharmacology; Humans; In Vitro Techniques; Indoles/chemistry; Indoles/pharmacology; Irinotecan; Mice; Microsomes, Liver/metabolism; Topoisomerase I Inhibitors; Transplantation, Heterologous

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Collection: 01-internacional Database: MEDLINE Main subject: Camptothecin / Carbazoles / Glucosides / Indoles / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Type: Article Affiliation country: United States

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