Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin.

McGuigan, Christopher; Thiery, Jean-Christophe; Daverio, Felice; Jiang, Wen G; Davies, Gaynor; Mason, Malcolm

McGuigan, Christopher; Thiery, Jean-Christophe; Daverio, Felice; Jiang, Wen G; Davies, Gaynor; Mason, Malcolm.

Affiliation

McGuigan C; Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK. mcguigan@cardiff.ac.uk

Bioorg Med Chem ; 13(9): 3219-27, 2005 May 02.

Article in En | MEDLINE | ID: mdl-15809157

Subject(s)

Amides/chemistry; Amides/pharmacology; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Bromodeoxyuridine/analogs & derivatives; Phosphoric Acids/chemistry; Phosphoric Acids/pharmacology; Amides/chemical synthesis; Antineoplastic Agents/chemical synthesis; Bromodeoxyuridine/chemical synthesis; Bromodeoxyuridine/pharmacology; Cell Line, Tumor; Cell Survival/drug effects; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Phosphoric Acids/chemical synthesis; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphoric Acids / Bromodeoxyuridine / Amides / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2005 Type: Article Affiliation country: United kingdom

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