Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

Llauger, Laura; He, Huazhong; Kim, Joungnam; Aguirre, Julia; Rosen, Neal; Peters, Ulf; Davies, Peter; Chiosis, Gabriela

Llauger, Laura; He, Huazhong; Kim, Joungnam; Aguirre, Julia; Rosen, Neal; Peters, Ulf; Davies, Peter; Chiosis, Gabriela.

Affiliation

Llauger L; Department of Medicine and Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

J Med Chem ; 48(8): 2892-905, 2005 Apr 21.

Article in En | MEDLINE | ID: mdl-15828828

Subject(s)

Adenine/analogs & derivatives; Adenine/chemical synthesis; Antineoplastic Agents/chemical synthesis; HSP90 Heat-Shock Proteins/antagonists & inhibitors; Sulfones/chemical synthesis; Sulfoxides/chemical synthesis; Adenine/chemistry; Adenine/pharmacology; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Binding, Competitive; Cell Line; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Structure-Activity Relationship; Sulfones/chemistry; Sulfones/pharmacology; Sulfoxides/chemistry; Sulfoxides/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Sulfoxides / Adenine / HSP90 Heat-Shock Proteins / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Type: Article Affiliation country: United States

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