Capture of recombinant ricin A chain by a bispecific anti-RTA:anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice.

Pimm, M V; Robins, R A; Baldwin, R W

Capture of recombinant ricin A chain by a bispecific anti-RTA:anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice.

Pimm, M V; Robins, R A; Baldwin, R W.

Affiliation

Pimm MV; Cancer Research Campaign Laboratories, University of Nottingham, UK.

J Cancer Res Clin Oncol ; 118(5): 367-70, 1992.

Article in En | MEDLINE | ID: mdl-1583066

ABSTRACT

ABSTRACT

A bispecific antibody against carcinoembryonic antigen (CEA) and ricin A chain has been shown to localise in a CEA-producing human tumour xenograft. When labelled recombinant ricin A chain was subsequently injected there was uptake into tumours, indicating that this bispecific antibody can capture or carry toxin into tumour deposits.

Subject(s)

Antibodies, Monoclonal/therapeutic use; Carcinoembryonic Antigen/analysis; Carcinoma/therapy; Immunotoxins/administration & dosage; Ricin/therapeutic use; Stomach Neoplasms/therapy; Animals; Carcinoembryonic Antigen/immunology; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Recombinant Proteins/immunology; Recombinant Proteins/therapeutic use; Ricin/immunology; Transplantation, Heterologous

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Collection: 01-internacional Database: MEDLINE Main subject: Ricin / Stomach Neoplasms / Carcinoma / Carcinoembryonic Antigen / Immunotoxins / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: J Cancer Res Clin Oncol Year: 1992 Type: Article Affiliation country: United kingdom

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